Question: How to simplify and substitute parameters in expression?

I have a equation

((D@@2)(theta))(eta) = -(1/2)*(D(theta))(eta)*(-2*(D(phi))(eta)*beta*epsilon*lambda*D[B]+2*(D(phi))(eta)*beta*epsilon*mu*D[B]+f(eta)*sin(alpha)*beta*nu+2*(D(theta))(eta)*gamma*epsilon*D[t]-2*(D(theta))(eta)*beta*epsilon*D[t]+cos(alpha)*beta*eta*nu)/(beta*sigma)

and a parameters expression

Pr:=nu/sigma; N[b] := epsilon*D[B](mu-lambda)/sigma; N[t] := epsilon*D[t](gamma-beta)/(gamma*sigma); Le := nu/D[B]

How can I seperate common terms and substitute this parameters and got this following expression

((D@@2)(theta))(eta) = -(1/2)*Pr*(D(theta))(eta)*eta*cos(alpha)-(1/2)*Pr*(D(theta))(eta)*sin(alpha)*f(eta)-N[b]*(D(theta))(eta)*(D(phi))(eta)-N[t]*(D(theta))(eta)

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